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Recurrence Rates of Major Depressive Disorder

The likelihood of experiencing a subsequent episode of major depressive disorder increases with each new occurrence. After a single episode, there is a 50% to 60% chance of having a second one. This probability rises to 70% for a third episode after two have occurred, and it further increases to 90% for a fourth episode after three have occurred.

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Updated 2025-10-09

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