Renin-Angiotensin System (RAS) Activity May Contribute to COVID-19 Morbidity and Mortality in Obese Patients
Ang II is a hormone that is regulated by the RAS. The excessive adipose tissue associated with obesity is known to secrete this molecule which stimulates inflammation, insulin resistance, oxidative stress, and vasoconstriction. Insulin resistance can exacerbate these conditions by further stimulating the RAS. A relationship exists between pancreatic beta islet cells (B-cells) and the RAS: B-cell dysfunction leads to increased expression AT1R, the receptor for Ang II, and insulin resistance while RAS inhibition increases B-cell function and insulin sensitivity.
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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