Risk and prognostic factors for Depressive Disorder Due to Another Medical Condition vary by the underlying illness. Following a stroke (cerebrovascular accident), depression is most likely to occur shortly after the event, with left frontal lesions posing the greatest risk. However, depression onset 2 to 6 months post-stroke shows no such anatomical association, suggesting alternative causes. For Parkinson's disease, early onset, severe motor symptoms, and longer disease duration are associated with increased depression risk. In traumatic brain injury (TBI), depression is more likely in women, those with a prior history of depression, early psychiatric symptoms, lower brain volume, and unemployment.