Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis and is endemic to many parts of the world. Of concern is the potential for co-infection with COVID-19 as both are spread via respiratory droplets and present with similar clinical symptoms. Due to the immunomodulatory nature of SARS-CoV-2, reactivation of latent TB infection is possible. Most diagnosis of COVID-19 may also miss TB in due to non-specific clinical features common to both diseases. TB infection may also be correlated to more severe COVID-19 disease progression, especially within endemic areas such as China and India. Active and latent TB infection can be considered to be risk factors for COVID-19. Tuberculosis should also be considered during diagnosis where patients are undergoing prolonged or unexplained clinical features.