1Cademy - SARS-CoV-2-targeted anti-viral miRNA analyzed in <br>Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

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Spike surface glycoprotein mutation and functional analysis of Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

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SARS-CoV-2-targeted anti-viral miRNA analyzed in Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

The study also found 6 out of the 9 predicted miRNA actually targeted SARS-CoV-2 genes by using PsRNATarget analysis to compare sRNA sequence and target mRNA sequence. It is important to note that these miRNA targets are not present in SARS or MERS genomes. These miRNAs function by cleaving their target sites.
The study identified one miRNA (hsa-miR-27b) that only targets the SARS-CoV-2 genome from India. This specific miRNA is known to target host IFN-gamma signaling pathways in specific viral infections,
Host anti-viral miRNA predicted to target spike glycoprotein of SARS-CoV-2 were also identified