1Cademy - Spike surface glycoprotein mutation and functional analysis of Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

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Results of Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

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Spike surface glycoprotein mutation and functional analysis of Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

Differences in the spike glycoproteins of SARS-CoV-2 and SARS-CoV were observed, including six frameshift mutations and 1 insertion in the genome. There were also mutations in regions that correspond to high immune response, which can effect antigenic and immunogenic changes of the virus. Mutations in the receptor-binding domain (RBD) domain were also observed with sequence alignment. Through SNP analysis it was observed that these mutations can lead to decrease in stability without changing their properties.

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Updated 2020-08-16

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