In the case of the interferon-dependent response that occurs when MAVS has localized in the mitochondria, it first required the detection of viral RNA which leads to subsequent activation of the Rig-I-like receptor, RLR, pathway. The detection of the viral RNA is carried out by the cytosolic sensors MDA5 gene and RIG-I. 

Interferon-Dependent Response: Detection

In order to understand the significance of the compromising of MAVS by ORF9b, it is important to understand the role that MAVS, Mitochondrial Antiviral Signaling protein, plays in immunity against viruses. The MAVS protein can be localized in two regions: peroxisomes (oxidative membrane-bound organelles) or the mitochondria. The localization of MAVS affects whether the response produced is interferon-independent (fast and occurs early) or interferon-dependent (stable and late response). 

Ohio State University, Columbus

The primary role of the MAVS signalosome seems to be in inducing apoptosis of the cell after detection of viral nucleic acids (viral RNA) and apoptosis (followed by subsequent autophagy) is a crucial aspect in the antiviral response.

Introduction to the function of the MAVS Signalosome

Jacobs, J. L., & Coyne, C. B. (2013). Mechanisms of MAVS regulation at the mitochondrial membrane. Journal of molecular biology, 425(24), 5009-5019.

Learn Before

Related

Learn After