The synapse is the junction between two nerve cells (neurons) where signals are transmitted. This process begins when the presynaptic cell releases chemical messengers called neurotransmitters into the synaptic space. These neurotransmitters then travel across the gap and bind to specific receptors on the postsynaptic cell, thereby passing on the signal. After signaling, neurotransmitters are often cleared from the synapse through reuptake, where they are reabsorbed by the presynaptic cell. This reuptake process can be targeted by medications, such as reuptake inhibitors, which block reabsorption and increase the concentration of neurotransmitters in the synapse.