Tulane University

Georgetown University

- Pathogenesis/Vector
- Presentation of Maternal Infection
- Diagnosis
- Fetal/Neonatal Abnormalities
- Vaccines

Rift Valley Fever

A viral disease most often spread to humans from domesticated animals in sub-Saharan Africa. Rift Valley Fever is more likely to cause severe illness in the animals than in the humans the virus is spread to.

Nausheen, F., S. Bashir, S., &amp; N. Atapattu, D. (2018). Pregnancy associated arbovirus infections. Clinical Microbiology and Infectious Diseases, 3(2). https://doi.org/10.15761/cmid.1000138 

Pregnancy Associated Arbovirus Infections

IgM-ELISA, antigen detection ELISA and PCR diagnostic tests are used to detect Rift Valley Fever

Diagnosing Rift Valley Fever

Intereferon Beta production is inhibited resulting in cell death. The Aedes and Culex species of mosquitoes are the vectors that transmit the arbovirus to susceptible populations. 

Rift Valley Fever Pathogenesis/Vector

Clinical manifestations of Rift Valley Fever in pregnant women include fever, joint pain, rash, hepatic dysfunction, meningitis and hemorrhage. 

Maternal Rift Valley Fever Infection Presentation

Abortions, rash, hepato-splenomegaly with ALT/AST elevation and bleeding diathesis

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