1Cademy - Connection Between DRD2, Parvalbumin Interneurons, and Schizophrenia

Concept

Connection Between DRD2, Parvalbumin Interneurons, and Schizophrenia

Selective dopamine D₂ receptor deletion from parvalbumin interneurons in mice causes a dysregulated dopaminergic system - including impaired inhibitory activity in the ventral hippocampus - since the D₂ receptor is necessary to modulate pyramidal neuron activity. The modulation of these interneurons may prevent overall dopaminergic dysregulation
Disrupted parvalbumin interneuron (PVI) function is thought to be an integral part of the pathophysiology of schizophrenia. PVIs drive cortical gamma oscillations, which are important for working memory and why such impairments are common in schizophrenia patients. They are also critical for proper excitatory/inhibitory balance in the brain.
Inhibitory activity starts to be promoted by DRD2 in the PVI around the time of adulthood, which could explain why schizophrenia manifests itself at this particular life stage

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Updated 2022-08-24

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