1Cademy - Prefrontal Cortex Endophenotypes as a Result of DRD2 Deletion

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Prefrontal Cortex Endophenotypes as a Result of DRD2 Deletion

Dopamine signaling through DRD2 regulates the spine morphology of pyrmidal neurons, so when DRD2 was deleted there was a marked decrease in dendritic spine density
Reduced glycogen synthase kinase 3ꞵ (Gsk3ꞵ) seen in schizophrenia patients - including DRD2 conditional mutant mice
Reduced mRNA expression of GAD67 and PV proteins reduced in the prefrontal cortex of conditional mutant mice without a significant change in parvalbumin interneuron (PVI) density
NMDA receptor subunit NR2B was significantly reduced in conditional DRD2 mutant mice
Alpha band (8-12 Hz) oscillations regulate the amplitude of the gamma band (30-70 Hz), and this was increased in the prefrontal cortex of conditional DRD2 mutant mice

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Updated 2022-08-24

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