1Cademy - The Effect of DRD2 Deletion from Parvalbumin Interneurons on Behavior

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The Effect of DRD2 Deletion from Parvalbumin Interneurons on Behavior

DRD2 conditional mutant mice (where DRD2 is deleted) show a range of endophenotypes associated with schizophrenia and had a limited or blunted pharmacological response to aripiprazole
Adult conditional mutant mice showed an significant increase in overall locomotor activity, an increase in anxiety or risk-taking behaviors (evidenced by an increased proportion of time spent in the open arms of the test maze and a decrease in the amount of marbles they buried), showed working memory impairments by alternating significantly less times between the arms of the maze, and were shown to unravel significantly less cotton to buid their nests (suggesting decreased motivation)
Conditional mice mutants spent an equal amount of time with new and familiar stimuli - which indicates they were treating all objects as if they were new, indicative of memory impairments.

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Updated 2022-08-24

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