Effects of SSRIs on Microglia
SSRIs appear to regulate the activation state of microglia in addition to their effects on the serotonergic system when studied in vitro. Fluoxetine (Prozac) and its metabolite, norfluoxetine, have been shown to induce apoptosis in microglia, which limits the amounts of neuroinflammation they can cause. There appear to be both direct and indirect (modulating amount of serotonin available to microglia, or changing the extracellular environment) mechanisms by which this is done.
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Behavioral Neuroscience
Psychology
Neuroscience (Neurobiology)
Social Science
Empirical Science
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Life Science / Biology
Biomedical Sciences
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A new medication is developed to treat a mood disorder. Its mechanism involves preventing the presynaptic neuron from reabsorbing a specific neurotransmitter after it has been released into the synapse. This results in a higher concentration of that neurotransmitter remaining in the synaptic cleft for a longer time. Based on this description, what is the primary way this medication enhances the neurotransmitter's effect?