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The Serotonin Theory

The serotonin theory claims that depression and other mental disorders are caused from an imbalance of serotonin in the brain, leading to a widespread use of SSRIs. This theory was first proposed in the 1960's and was publicized in the 1990's. SSRIs aim to increase serotonin levels in the synaptic cleft by blocking the reuptake of serotonin. However, the theory has been questioned in recent years, as studies haven’t consistently found a clear link between low serotonin and mental illnesses like depression.

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Updated 2025-06-14

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