A study where participants were given fish oil for 12 weeks showed an increase in EPA and DHA and a decrease in the concentration of omega-6 to omega-3. Thus, EPA and DHA lessen ARA production, preventing synthesis of eicosanoids. This also means that omega-3’s concentration is greater (responsible for reducing inflammation). EPA and DHA prevent inflammation by inhibiting leukocyte chemotaxis, increasing action of transcription factors that prevent inflammation, etc. The COX and LOX pathways are used to get rid of inflammation by the resolvins from EPA and protections from DHA. The entrance of neutrophils and cytokines into the endothelial tissue is inhibited. In COVID-19 patients, those given fish oil showed a decrease in cytokine levels.