Corticosteroids suppress the immune system by inhibiting proinflammatory genes that produce cytokines. They also lessen COX-2 functioning, which prevents prostaglandins from forming. However, when non-steroidal anti-inflammatory drugs block ARA action, involved in the formation of prostaglandins, blood vessels become constricted. This, in turn, results in increased expression of ACE2 receptors in the lungs and other organs, thus increasing the chances of getting COVID-19. Yet, there is still more information needed on non-steroidal anti-inflammatory drugs, such as Ibuprofen. Aspirin, however, has a different impact; it decreases the presence of prostaglandins and increases the presence of leukotrienes and lipoxins, preventing inflammation.