The prostaglandins produced by cyclooxygenase decrease blood pressure and both prevent and cause inflammation, as it has different receptors (E1-E4). Prostaglandins also increase the presence of neutrophils, which results in inflammation, as well as macrophages. In relation to inflammation, prostaglandins increase the presence of cytokines, as seen in those with COVID-19. Prostaglandins negatively impact the T-cells’ Th1 response, while increasing Th2 response, resulting in lack of protection against the viruses. In a study done on animals, those with influenza A experienced an increase in virus replication due to the formation of prostaglandins. However, prostaglandins decrease the risk of asthma through the decreased leukotriene production.