1Cademy - Expression of parvalbumin and calretinin mRNAs in area 9 of schizophrenic and control subjects

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Expression of parvalbumin and calretinin mRNAs in area 9 of schizophrenic and control subjects

Parvalbumin (PV) mRNA positive neurons were most highly distributed in prefrontal cortical layers II-IV. In schizophrenia patients, a 29% decrease in expression in layer III and a 35% decrease in layer IV was seen
Calretinin (CR) mRNA positive neurons were most highly distributed in prefrontal cortical layers I and II. There was no significant difference in CR mRNA expression in these layers in patients with schizophrenia
PV mRNA signals in area 9 of the prefrontal cortex are decreased in patients with schizophrenia but CR mRNA signals aren’t affected
Average optical density of PV mRNA was decreased by 30% in patients with schizophrenia
Grain density per PV mRNA-positive neuron showed a 22% decrease in patients with schizophrenia
Since there’s a collective decrease in PV mRNA expression levels in patients with schizophrenia, the balanced signal intensity ratio for CR to PV mRNA expression was seen to be significantly higher in patients with schizophrenia
PV mRNA reduction can’t be due to general deterioration of mRNA integrity in those with schizophrenia since CR mRNA (among other transcripts) didn’t differ between schizophrenia and control subjects
Reduction in PV mRNA levels could reflect changes in transcriptional regulation secondary to genetic predisposition to schizophrenia

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Updated 2022-08-15

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