1Cademy - Functional Connectivity in BPD

Concept

Functional Connectivity in BPD

The typical areas that have been subject to study are the nuclei clusters comprising the amygdalae and the prefrontal cortex (PFC) as their functionality and activation is abnormal relative to healthy controls.
- The amygdalae constitute part of the limbic system and play a role in the emotional response to a stimulus, most notably inducing physiological reactions to fear, anger, anxiety, and aggression.
  - Hyperarousal of the amygdalae give rise to the intense emotional responses that are characteristic of BPD.
- The PFC is a major contributor to our executive control, influencing emotional and motivational behaviors.
  - Diminished efficacy of top-down cortical modulation—wherein the brain uses models, ideas, and expectations to interpret sensory information—is observed in BPD, as misinterpretation of events often invokes the onset of a crisis.
Both the amygdalae and the PFC are associated with different neural networks.
- Within the SN, a network that detects and incorporates emotional and sensory stimuli, the amygdalae are considered a subcortical node.
- Subsections of the PFC are classified as cortical nodes in the DFN, a network involved in various functions but guessed at being the primary determinant of the neurological basis for the self.
Abnormal neuronal connectivity of the amygdalae and the PFC may be an underlying cause of the impaired communication between the aforementioned neural networks often reported in BPD.

0

1

Updated 2021-11-17

Contributors are:

Who are from:

References