Comparison of Unfractionated and Low-Molecular-Weight Heparins in Anti-ACE2-Treated RT4 Cells
In RT4 cells pre-treated with anti-ACE2 antibodies, unfractionated heparin strongly inhibited SARS-CoV-2 S1S2 protein binding, whereas the low-molecular-weight heparins dalteparin and enoxaparin acted as partial inhibitors and were less potent than unfractionated heparin.
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SARS-CoV-2 (COVID-19)
Biomedical Sciences
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Comparison of Unfractionated and Low-Molecular-Weight Heparins in Anti-ACE2-Treated RT4 Cells
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Graphic of spike protein binding to heparan sulfate
Comparison of Unfractionated and Low-Molecular-Weight Heparins in Anti-ACE2-Treated RT4 Cells