1Cademy - Methods of Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial

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Methods of Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial

The Randomised Evaluation of COVID-19 Therapy (RECOVERY) is a randomized, controlled, open-label, platform trial that involves 176 hospitals in the United Kingdom
The study was done on hospitalized COVID-19 patients with clinically suspected or laboratory confirmed SARS-CoV-2 infection, excluding patients with prolonged electrocardiograph QTc interval
Variables taken into account for randomization: age, sex, level of respiratory support required, days since symptom onset, and predicated 28-day mortality risk (estimated within a 95% confidence interval)
1561 randomly allocated to receive hydroxychloroquine vs 3155 patients concurrently allocated to usual care alone
Patients who received hydroxychloroquine were given a loading dose of 4 tablets (800mg) at 0 and 6 hours and 2 tablets (400mg) 12 hours after the initial dose and every 12 hours for the next 9 days (or until discharge or death, whichever came first)
An online follow-up form was to be completed once patients were discharged, had died, or at 28 days of randomization (whichever came first)

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Updated 2020-08-07

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