Since COVID-19’s inception in December 2019, healthcare workers (HCW) have been the primary persons involved in the screening and treatment of the disease. However, HCW are not immune to its psychological effects. Various reasons exist for these adverse outcomes which include: high infection rates among HCW, excessive workload, inadequate PPE, an oversaturated media presence, and the feeling of insufficient support. Reasons specific to the disease itself include its rapid spread, mode of transmission, an undefined protocol of treatment, and lack of vaccine. Compared to doctors, nurses have higher rates of depressive and anxiety symptoms. Thus, it is important to consider mental health evaluation in the regular screening of HCW, followed with implementation of mental health teams.