University of Michigan - Ann Arbor

Diseases that require arthropod vectors:
- Anaplasmosis
- Ehrlichiosis
- Epidemic Typhus
- Murine (Endemic) Typhus
- Rocky Mountain Spotted Fever
- Lyme Disease
- Relapsing Fever
- Trench Fever

Zoonotic Febrile Diseases

Anaplasmosis is caused by the pathogen *Anaplasma phagocytophilum*.

Anaplasmosis

Ehrlichiosis is caused by caused by the BSL-2, obligate intracellular pathogen *Ehrlichia chaffeensis*.

Ehrlichiosis

Epidemic typhus is a severe and highly infectious disease caused by the bacterium *Rickettsia prowazekii* and spread via body lice. It commonly occurs during wars and mass human migrations, infecting endothelial cells to cause blood vessel lining inflammation, high fever, abdominal pain, and potential delirium.

Epidemic Typhus

Murine (or endemic) typhus is a relatively mild infectious disease caused by the bacterium *Rickettsia typhi*. It is typically observed in the southwestern United States during warm seasons.

Murine (Endemic) Typhus

Rocky Mountain spotted fever is a life-threatening form of meningoencephalitis (inflammation of the membranes wrapping the brain) caused by the bacterium *Rickettsia rickettsii* and transmitted to humans via the bite of an infected tick.

Rocky Mountain Spotted Fever

Lyme Disease is caused by the spirochete *Borrelia burgdorferi*

Lyme Disease

Relapsing fever is a zoonotic disease characterized by recurring febrile episodes. It can be caused by the spirochetes *Borrelia recurrens* (responsible for louseborne relapsing fever) and *Borrelia hermsii* (responsible for tickborne relapsing fever).

Relapsing Fever

Trench Fever is caused by the pathogen *Bartonella quintana*.

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