*Cytophaga* is a genus of motile, aquatic bacteria within the CFB group that move by gliding.

*Cytophaga*

*Fusobacterium* is a genus of bacteria within the CFB group that inhabit the human oral cavity and have the potential to cause severe infectious diseases.

*Fusobacterium*

*Bacteroides* is the largest genus in the CFB group, comprising dozens of species that are abundant inhabitants of the human large intestine, making up approximately $${}30$$% of the gut microbiome, with populations reaching up to $${}100$$ billion cells per gram of feces.

*Bacteroides*

The *Cytophaga-Flavobacterium-Bacteroides* (CFB) group is a phylum of phylogenetically diverse, rod-shaped, gram-negative nonproteobacteria. These bacteria are anaerobic organoheterotrophs and avid fermenters that share similarities in their DNA nucleotide sequences and are adapted to anaerobic environments, such as the human mouth or gut, where they can be mutualistic or pathogenic.

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Non-proteobacteria gram-negative bacteria are a group of gram-negative bacteria that do not belong to the Proteobacteria phylum. This group includes spirochetes, the Cytophaga-Flavobacterium-Bacteroides (CFB) group, Planctomycetes, and Chlamydia species.

Non-proteobacteria Gram Negative Bacteria

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Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.

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Planctomycetes is a phylum of aquatic bacteria inhabiting freshwater, saltwater, and brackish environments. They reproduce by budding rather than binary fission, producing a motile swarmer cell from a maternal cell. This swarmer cell eventually attaches to a surface using an appendage called a holdfast and differentiates into an immobile (sessile) cell, which is the only stage capable of reproduction.

Planctomycetes

Gram-negative cells possess a cell envelope with a significantly thinner layer of peptidoglycan—no more than about $${}4$$ nm thick—compared to gram-positive cells. Their overall cell envelope structure is highly complex, featuring a periplasmic space and an outer membrane located external to the peptidoglycan layer.

Gram Negative Cell Walls

The *Chlamydia* genus consists of many pathogens. They spread very easily from host to host because they form elementary bodies during their life cycle. These are spore-like which allows *Chlamydia* to be metabolically inactive until they are in a host environment.

*Chlamydia*

*Cytophaga-Flavobacterium-Bacteroides* (CFB)

Spirochetes are gram-negative bacteria characterized by long, spiral-shaped bodies that can reach lengths up to $${}250$$ μm. Due to their extreme thinness, they are difficult to view under conventional brightfield microscopes, typically requiring darkfield fluorescent microscopy instead, and are highly difficult or impossible to culture in a laboratory.

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