- Tests pituitary-adrenal function
- Participant is given dexamethasone (synthetic glucocorticoid hormone)
- Cause a decline in the production of adrenal corticosteroids 

Dexamethasone Suppression Test

Based on the provided case study, predict a likely finding related to stress hormone levels and explain the physiological reasoning for this prediction, considering the individual's history.

Interpreting Physiological Data in a Clinical Context

Research has long indicated that individuals with depression often exhibit abnormal levels of cortisol, a key stress hormone released by the neuroendocrine system during the body's fight-or-flight response. Elevated cortisol is particularly prevalent in depressed individuals who have experienced early life trauma, such as childhood abuse or the loss of a parent.

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- Levels of adrenal glucocorticoids are abnormally high
- Makes you more prone to depression
- Causes include hormone-secreting tumors, or treatment with synthetic glucocorticoids
- Depression occurs early in those with this syndrome
- Other typical signs include obesity and unusual growth and distribution of body hair
- These sign suggest that dysfunction of the hypothalamic-pituitary-adrenal axis may be involved in depression

Cushing's Syndrome

The Hypothalamic-Pituitary-Adrenal (HPA) axis is a crucial neuroendocrine system that orchestrates the body's response to stress. While highly active during a stress response, its hormonal cascade operates more slowly than the immediate reaction of the sympathetic nervous system. The process begins when the hypothalamus releases corticotropin-releasing factor (CRF), which signals the pituitary gland to secrete adrenocorticotropic hormone (ACTH). ACTH then travels to the adrenal glands, stimulating them to release hormones like cortisol into the bloodstream. This hormonal sequence ultimately provides the body with the energy needed to manage the stressor.

Hypothalamic-Pituitary-Adrenal (HPA) Axis

Breedlove, S. & Watson, N. (2017). Behavioral neuroscience, eighth edition. Oxford University Press.

Behavioral Neuroscience 8th Edition

Spielman, R. M., Jenkins, W. J., & Lovett, M. D. (2020, April 22). Psychology (2nd ed.). OpenStax. https://openstax.org/books/psychology-2e/pages/1-introduction

OpenStax Psychology (2nd ed.) Textbook

HPA Axis Dysfunction and Cortisol Levels in Depression

- Higher urinary cortisol levels have been found in BPD patients compared to controls.
- When BPD patients were divided according to the presence of high or low number of PTSD symptoms, high cortisol levels were found only in BPD patients with a low number of PTSD symptoms.
- Found an exaggerated ACTH and cortisol response during the DEX/CRH test in the blood of BPD female subjects who had experienced childhood abuse.

HPA Axis in BPD

Comfort eating is eating as a way to soothe negative emotions. Research showed that eating sweet high-fat food can blunt the activity in the hypothalamic-pituitary-adrenal axis (HPA), a neuroendocrine system that in humans has been shown to regulate psychological processes, including negative emotions.

Comfort Eating(Emotional Eating)

Response to prolonged periods of psychological stress (that can lead to poor mental health) involving the endocrine system and its release of corticosteroids, which increases over time as a result of this.

Chronic Stress is the result in an Overactivation of the HPA-axis

Cortisol is a stress hormone. During the beginning of an exposure to a stressor, it provides the body with energy. However, long periods of exposure to stressors leads to sustained levels of cortisol, which in turn weakens the immune system.

Cortisol Hormone

A Stressful Interaction Causes the Release of Cortisol by the...?

The Hypothalamic-Pituitary-Adrenal (HPA) axis is visually represented by showing the locations of its key components within the human body. The hypothalamus and pituitary gland are located within the brain, while the adrenal glands are situated on top of the kidneys. Arrows are used to depict the flow of hormonal signals, starting from the hypothalamus, moving to the pituitary gland, and finally reaching the adrenal glands.

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