Concept

Hypothalamic-Pituitary-Adrenal (HPA) Axis

The Hypothalamic-Pituitary-Adrenal (HPA) axis is a crucial neuroendocrine system that orchestrates the body's response to stress. While highly active during a stress response, its hormonal cascade operates more slowly than the immediate reaction of the sympathetic nervous system. The process begins when the hypothalamus releases corticotropin-releasing factor (CRF), which signals the pituitary gland to secrete adrenocorticotropic hormone (ACTH). ACTH then travels to the adrenal glands, stimulating them to release hormones like cortisol into the bloodstream. This hormonal sequence ultimately provides the body with the energy needed to manage the stressor.

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Updated 2025-10-06

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