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Sodium-Potassium Pump
The sodium-potassium pump is an active transport mechanism in the neuronal membrane that is crucial for maintaining the resting potential. It works by continuously moving ions against their concentration gradients, expelling three positively charged sodium ions (Na+) from the cell for every two positively charged potassium ions (K+) it imports. This unequal exchange of positive ions results in a net loss of positive charge from the neuron's interior, thereby creating the net negative charge inside the cell.
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Nernst Equation
Measuring Membrane Potential
Microelectrode
Goldman Equation
Sodium-Potassium Pump
Pressures on Ions During Resting Potential
Imagine a neuron is exposed to a substance that specifically blocks the protein pump responsible for moving three sodium ions out of the cell for every two potassium ions it moves in. Assuming ion channels still allow for some passive leakage, what would be the most likely consequence for the neuron's resting membrane potential over time?
Imagine a neuron is exposed to a substance that specifically blocks the protein pump responsible for moving three sodium ions out of the cell for every two potassium ions it moves in. Assuming ion channels still allow for some passive leakage, what would be the most likely consequence for the neuron's resting membrane potential over time?