Concept

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study: Results

582 individuals had PCR-confirmed infection. Demographics: Median age: 5 yrs old Sex ratio: 1.15 males per females 145 (25%) pre-existing medical conditions

363 individuals (62%) were admitted to the hospital, with 48 (8%) requiring ICU admission. 507 (87%) didn’t require respiratory support while 75 (13%) required support, with 25 (4%) requiring mechanical ventilation. The authors also observed that the majority of intubated children required prolonged ventilation of 1 week or more.

The authors identified risk factors for ICU admission: being younger than1 month old (OR 5.06, 95% CI 1.72,14.87), male (OR 2.12, 95% CI 1.06-4.21), pre-existing medical conditions (OR 3.27, 95% CI 1.67-6.42) and lower respiratory tract infection upon arrival at the facility (OR 10.46, 95% CI 5.16-21.23). Hydroxychloroquine was used on 40 patients, remdesivir on 17, lopinavir-ritonavir on 6, and oseltamivir on 3. Four individuals died at study end, with 25 individuals still recovering from illness (CFR 0.69, 95% CI 0.2-1.82).

Household interactions played a large role in transmission of COVID-19: 324 individuals (56%) were infected by a parent and 24 (4%) by a sibling. The remaining 234 children (40%) were unknown/ someone outside of the family.

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Updated 2020-07-30

Tags

SARS-CoV-2 (COVID-19)

Biomedical Sciences