Prader-Willi Syndrome (PWS) is a genetic condition linked to hypothalamic abnormalities. These abnormalities are thought to cause the syndrome's characteristic symptoms, including a constant, intense feeling of hunger and a slower metabolism, making PWS the leading genetic cause of severe childhood obesity. Because the hypothalamus also regulates sexual behavior, many individuals with PWS do not achieve sexual maturity during adolescence. Due to the risk of overeating, those with PWS, especially children, often need constant supervision and may face related cognitive and emotional challenges.